Alzheimer’s Disease and COVID-19 Share a Genetic Risk Factor

10 mins read

An anti-viral gene that impacts the risk of both Alzheimer’s disease and severe Covid-19 has been identified by a UCL-led research team.

The researchers estimate that one genetic variant of the OAS1 gene increases the risk of Alzheimer’s disease by about 3-6% in the population as a whole, while related variants on the same gene increase the likelihood of severe Covid-19 outcomes.

The findings, published in Brain, could open the door for new targets for drug development or tracking disease progression in either disease, and suggest that treatments developed could be used for both conditions. The findings also have potential benefits for other related infectious conditions and dementias.

Lead author Dr. Dervis Salih (UCL Queen Square Institute of Neurology and UK Dementia Research Institute at UCL) said: “While Alzheimer’s is primarily characterized by harmful build-up of amyloid protein and tangles in the brain, there is also extensive inflammation in the brain that highlights the importance of the immune system in Alzheimer’s. We have found that some of the same immune system changes can occur in both Alzheimer’s disease and Covid-19.

“In patients with severe Covid-19 infection there can also be inflammatory changes in the brain. Here we have identified a gene that can contribute to an exaggerated immune response to increase risks of both Alzheimer’s and Covid-19.”

For the study the research team sought to build on their previous work, which found evidence from a large dataset of human genomes, to suggest a link between the OAS1 gene and Alzheimer’s disease.

The OAS1 gene is expressed in microglia, a type of immune cell that constitutes around 10% of all cells found within the brain. Investigating the gene’s link to Alzheimer’s further, they sequenced genetic data from 2,547 people, half of whom had Alzheimer’s disease. They found that people with a particular variation, called rs1131454, of the OAS1 gene were more likely to have Alzheimer’s disease, increasing carriers’ baseline risk of Alzheimer’s by an estimated 11-22%. The new variant identified is common, as just over half of Europeans are believed to carry it, and it has a bigger impact on Alzheimer’s risk than several known risk genes.

Their findings add OAS1, an anti-viral gene, to a list of dozens of genes now known to affect a person’s risk of developing Alzheimer’s disease.

The researchers investigated four variants on the OAS1 gene, all of which dampen its expression (activity). They found that the variants increasing the risk of Alzheimer’s disease are linked (inherited together) with OAS1 variants recently found to increase the baseline risk of needing intensive care for Covid-19 by as much as 20%.

As part of the same research, in immune cells treated to mimic the effects of Covid-19, the researchers found that the gene controls how much the body’s immune cells release pro-inflammatory proteins. They found that microglia cells where the gene was expressed more weakly had an exaggerated response to tissue damage, unleashing what they call a ‘cytokine storm,’ which leads to an autoimmune state where the body attacks itself.

OAS1 activity changes with age, so further research into the genetic network could help to understand why older people are more vulnerable to Alzheimer’s, Covid-19, and other related diseases.

PhD student Naciye Magusali (UK Dementia Research Institute at UCL) said: “Our findings suggest that some people may have increased susceptibility to both Alzheimer’s disease and severe Covid-19, irrespective of their age, as some of our immune cells appear to engage a common molecular mechanism in both diseases.”

Following the outbreak of the Covid-19 pandemic, researchers from the UK Dementia Research Institute at UCL have pivoted their attention to investigating the long-term neurological consequences of the virus. Using biomarkers found in the blood and fluid surrounding the central nervous system, they are aiming to track neuroinflammation and injury to the neurons.

Dr. Salih said: “If we could develop a simple way of testing for these genetic variants when someone tests positive for Covid-19, then it might be possible to identify who is at greater risk of needing critical care, but there is plenty more work to be done to get us there. Similarly, we hope that our research could feed into the development of a blood test to identify whether someone is at risk of developing Alzheimer’s before they show memory problems.

“We are also continuing to research what happens once this immune network has been activated in response to an infection like Covid-19, to see whether it leads to any lasting effects or vulnerabilities, or if understanding the brain’s immune response to Covid-19, involving the OAS1 gene, may help to explain some of the neurological effects of Covid-19.”

Reference: “A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene” by Naciye Magusali, Andrew C Graham, Thomas M Piers, Pantila Panichnantakul, Umran Yaman, Maryam Shoai, Regina H Reynolds, Juan A Botia, Keeley J Brookes, Tamar Guetta-Baranes, Eftychia Bellou, Sevinc Bayram, Dimitra Sokolova, Mina Ryten, Carlo Sala Frigerio, Valentina Escott-Price, Kevin Morgan, Jennifer M Pocock, John Hardy and Dervis A Salih, 7 October 2021, Brain.
DOI: 10.1093/brain/awab337

The study involved researchers at UCL, University of Nottingham, Cardiff University, and Nottingham Trent University. The work was funded by the UK Dementia Research Institute (DRI), which receives its funding from the DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. Further support was provided by Alzheimer Nederland, Erasmus, the European Union’s Horizon 2020 programme, the European Federation of Pharmaceutical Industries and Associations and the National Institute for Health Research UCLH Biomedical Research Centre.

https://www.deviantart.com/billukha/journal/CFB-College-football-Week-7-Live-stream-reddit-895043537

https://console.mytrendingstories.com/article/single/college-football-live-stream-reddit-weeeng

https://pastebin.com/yunXjTLk

https://kukooo.com/jobs/sales/ncaaf-live-stream-college-football-live-stream-free-reddit_i102434

https://vocus.cc/article/616ace42fd897800011c7603

https://blog.goo.ne.jp/sadsfd/e/4a8610c1d41c7ad978a6b6eb30b0b2c7

https://pasteio.com/xDv6xO6hirNc

https://paiza.io/projects/b0c5TEwo-jiGjSbmoTbK7Q?language=php

https://www.bankier.pl/forum/temat_ncaaf-live-stream-college-football-live-stream-free-reddit,50287179.html

https://ideone.com/TXp0Pv

https://www.deviantart.com/billukha/journal/Livestreams-UCF-vs-Cincinnati-Live-Stream-reddit-895041867

https://www.deviantart.com/billukha/journal/W-7-UCF-vs-Cincinnati-LiveStream-reddit-free-895041914

https://www.deviantart.com/billukha/journal/h2h-UCF-vs-Cincinnati-FREE-LiveStream-reddit-895041969

https://www.deviantart.com/billukha/journal/Live-Michigan-State-vs-Indiana-Live-Stream-reddit-895042061

https://www.deviantart.com/billukha/journal/W-7-Michigan-State-vs-Indiana-LiveStream-reddit-895042107

https://www.deviantart.com/billukha/journal/h2h-Michigan-State-vs-Indiana-FREE-LiveStream-895042162

https://www.deviantart.com/billukha/journal/Livestreams-Oklahoma-State-vs-Texas-Live-REDDIT-895042210

https://www.deviantart.com/billukha/journal/W-7-Oklahoma-State-vS-Texas-LiveStream-reddit-free-895042240

https://www.deviantart.com/billukha/journal/h2h-Oklahoma-State-vs-Texas-LiveStream-reddiT-895042274

https://www.deviantart.com/billukha/journal/LivE-Auburn-vs-Arkansas-Live-Stream-reddit-16-10-895042314

https://www.deviantart.com/billukha/journal/W-7-Auburn-vs-Arkansas-LiveStream-reddit-free-895042356

https://www.deviantart.com/billukha/journal/h2h-Auburn-vs-Arkansas-FREE-Live-Stream-reddit-895042391

https://www.deviantart.com/billukha/journal/Livestreams-Florida-vs-LSU-Live-reddit-16-10-895042447

https://www.deviantart.com/billukha/journal/W-7-Florida-vs-LSU-LiveStream-reddit-free-10-16-895042493

https://www.deviantart.com/billukha/journal/h2h-Florida-vs-LSU-FREE-Live-Stream-reddit-895042548

https://www.deviantart.com/billukha/journal/LiveReddit-Texas-AM-vs-Missouri-Live-Stream-895042603

https://www.deviantart.com/billukha/journal/W-7-Texas-AampM-vs-Missouri-LiveStream-reddit-fr-895042642

https://www.deviantart.com/billukha/journal/h2h-Texas-AM-vs-Missouri-FREE-Live-Stream-reddit-895042691

https://www.deviantart.com/billukha/journal/Livestreams-Nebraska-vs-Minnesota-Live-Reddit-Fr-895042733

https://www.deviantart.com/billukha/journal/Week7-Nebraska-vs-Minnesota-LiveStream-reddit-free-895042758

https://www.deviantart.com/billukha/journal/h2h-Nebraska-vs-Minnesota-FREE-LiveStream-reddit-895042783

https://www.deviantart.com/billukha/journal/Livestreams-Rutgers-vs-Northwestern-Live-REDDIT-895042810

https://www.deviantart.com/billukha/journal/W-7-Rutgers-vs-Northwestern-LiveStream-reddit-free-895042828

https://www.deviantart.com/billukha/journal/h2h-Rutgers-vs-Northwestern-FREE-Live-Stream-redd-895042856

https://www.deviantart.com/billukha/journal/streams-Yale-vs-UConn-Live-Stream-reddit-16-Oct-895043011

https://www.deviantart.com/billukha/journal/W-7-Yale-vs-UConn-LiveStream-reddit-free-895043057

https://www.deviantart.com/billukha/journal/h2h-Yale-vs-UConn-FREE-Live-Stream-reddit-895043090

https://www.deviantart.com/billukha/journal/Livestreams-Tulsa-vs-South-Florida-Live-Reddit-895043135

https://www.deviantart.com/billukha/journal/W-7-Tulsa-vs-South-Florida-LiveStream-reddit-free-895043162

https://www.deviantart.com/billukha/journal/h2h-Tulsa-vs-South-Florida-FREE-LiveStream-reddiT-895043199

https://www.deviantart.com/billukha/journal/Livestreams-Ohio-vs-Buffalo-Live-Stream-reddit-16-895043233

https://www.deviantart.com/billukha/journal/Week-7-Ohio-vs-Buffalo-LiveStream-reddit-free-895043272

https://www.deviantart.com/billukha/journal/h2h-Ohio-vs-Buffalo-FREE-LiveStream-reddit-895043317

https://www.deviantart.com/billukha/journal/Livestreams-Duke-vs-Virginia-Live-Stream-reddit-895043368

https://www.deviantart.com/billukha/journal/CFBStreams-Duke-vs-Virginia-LiveStream-reddit-free-895043404

https://www.deviantart.com/billukha/journal/h2h-Duke-vs-Virginia-FREE-LiveStream-reddit-895043433

Leave a Reply

Your email address will not be published.

Previous Story

Unique Benefits for Fat Loss: New Insight on How Resistance Training Burns Fat

Next Story

Parents have had a wake-up call about kids and tech Here’s